Welcome to the Cambridge Systems Biology Centre (CSBC). The recent UK government Research Assessment Exercise identified Functional Genomics and Systems Biology as a world-leading research activity in the University of Cambridge. The Cambridge Systems Biology Centre forms a focus for this type of research in Cambridge and is a trans-disciplinary research centre established by the Departments of Biochemistry and Genetics, but with Members and Associates from across the Schools of Biological Sciences, Clinical Medicine, Physical Sciences, and Technology. The Principal Investigators of CSBC provide the mix of ‘wet’ (experimental) and ‘dry’ (computational) skills that Systems Biology demands. CSBC has particular strengths in bioinformatics and computer/mathematical modelling, in transcriptomics and proteomics, and in the integration and analysis of large data sets. CSBC aims to translate state-of-the-art systems biology techniques being developed using model organisms to applications in plant science and medicine. CSBC hosts visiting researchers from across the university and the world and provides a friendly, dynamic, and highly interactive environment in which they can successfully pursue their research goals.